It is possible. There is a link to early life exposure to stress affecting the body’s natural response to stress. So, your exposure to stress in utero or fetal programming⁴ as well as  experiences as a young child can pre-program you into a maladaptive, unhealthy response to stress, changing the way that your hypothalamic-pituitary-adrenal axis (HPA) functions⁵. These are the master organs that balance the regulation systems of your body, most responsible for the way your body deals with stress.

IT IS NOT YOUR FAULT, BUT IT IS UP TO YOU TO DO SOMETHING ABOUT IT.

The Regulatory Systems Impacted In Irritable Bowel Syndrome

When you are under stress, whether it be emotional or physical stress, the body does not have the ability to differentiate⁶. Two processes occur in the body to try and maintain balance. The inflammatory arm of the immune system activates to try and burn off the stressor. The hypothalamic-pituitary-adrenal axis (a combination of the hormonal and nervous system⁷) also activates to turn off less important mechanisms that don’t deal with immediate life right now.

These three regulatory systems of the body, the immune, nervous and hormonal system’s goal in health is to keep everything in balance, everything functioning well. But under stress, they shut down non-vital functions for preservation of life. Therefore there’s dysregulation in these systems with IBS⁸. We also see an elevation of glucocorticoids and inflammatory markers.

So don’t be surprised if you find yourself with multiple conditions on top of your IBS. For me, I had both irritable bowel syndrome as well as polycystic ovarian syndrome (PCOS). These are often conditions that respond to an elevation of the body’s immune inflammatory messengers and the neurohormonal glucocorticoids.

Hormone Problems and IBS

Is this a coincidence then, that many women who have IBS also have PCOS? No it is not, because the body can only balance so much. In PCOS there are elevated levels of leptin, a hormone that affects food intake, energy balance and fat tissue stores but is also pro-inflammatory to the intestinal tract. Research shows that with irritable bowel syndrome there is also this elevated level of leptin in the intestine⁹.

When there is stress, many of our non-vital systems like being fertile, having regular periods, or having a healthy metabolism go into preservation mode, because the infinite intelligence of our bodies doesn’t want to use up resources because it has no idea how long the stressor will last.

Another co-existing hormonal problem that is common with IBS type symptoms, like constipation, is hypothyroid¹⁰.

Immune System Problems and IBS

The immune system is regulated by the microbiome. The ever important home of billions of bugs that live on our mucosal membrane and skin.

Healthy, friendly probiotics help to improve the mucosal immune system¹¹, whereas conbiotics™, as I like to call them, or pathogenic bacteria cause total dysfunction of the immune system¹².

This leads you susceptible to constantly getting sick. Overreacting to foods as your gut’s reaction to foods is based on the immune system. It is well known that people with IBS react to many foods such as lactose¹³, gluten¹⁴ and other components of wheat to name a few.

Nervous System Problems and IBS

Google IBS and you will soon find many links that discuss the coexistence of depression and anxiety with IBS, but also as a coexisting factor with most chronic conditions. Many say that it may be in response to the condition, but it very well may be the cause of the condition, (is it the chicken or the egg, which came first?) as stress significantly alters the bodies’ regulatory homeostatic mechanisms¹⁵.

Is Stress the Cause of IBS?

Stress is a root cause of many conditions and chronic diseases. It is likely that it is a root cause of IBS, as the overlap of anxiety, depression, hormonal disturbances and immune variations are all linked to irritable bowel syndrome.

Treatments for Irritable Bowel Syndrome

It’s no surprise that at present the majority of treatments and medicines for irritable bowel syndrome are tools that mediate the functions of these three regulatory systems of the immune, nervous and hormonal systems, as the gut is the main hub for all three.

Antidepressants and anti-anxiety medications have been used for IBS, as well as antibiotics such as Rifaximin, as a way to improve the gut microbiome¹⁶.